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LUCEY-DRISCOLL SYNDROME Mutations in the same gene cause Crigler- Najjar syndrome types I and II (, ) and Gilbert syndrome (). Disease name; Orpha number Synonym(s). Lucey-Driscoll syndrome An Orphanet summary for this disease is currently under development. However. Nonphysiologic neonatal jaundice – Maternal serum jaundice, also known as Lucey-Driscoll syndrome, is an autosomal recessive metabolic.

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Classes and Support Groups. Production of unconjugated hyperbilirubinaemia in full-term new-born infants following administration of pregnane-3 alpha20 beta -diol. Rare; 24 cases reported.

Left untreated, kernicterus may develop. A substance, probably a metabolite of gestational hormones inhibitor of uridine diphosphate [UDP]-glucuronosyltransferase activitythat inhibits bilirubin conjugation is responsible for the disease.

Other entities represented in this entry: A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Arias and Gartner ; Syndgome and Gross Lucey—Driscoll syndrome has an autosomal recessive pattern of inheritance.

Rare conditions Genetic, autosomal recessive Congenital onset. Educational Resources Added By: Disease Information Added By: Member feedback about Lucey—Driscoll syndrome: Crigler-Najjar syndrome, type II. Retrieved from ” https: Certain conditions originating in the perinatal period — Maternal causes of perinatal morbidity and mortality — Fetus or newborn affected by material conditions which may be unrelated to present pregnancy Causes – Lucey Driscoll syndrome Not supplied.

The inhibitor was present in these mothers in concentrations 4 to 10 times that syndome other pregnant mothers. Cause The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn.


CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used shndrome relied on for any diagnostic or treatment purposes.

Info Lucey Driscoll syndrome. Characterized by normal liver function tests, normal liver histology, delayed clearance of bilirubin from the blood, and mild jaundice that tends to fluctuate in severity, particularly after fasting.

Clinical Synopsis Toggle Dropdown. Only comments written in English can be processed. CC ]. Hyperbilirubinemia in breast-fed infants. Jaundice occurring in breast-fed neonate around the fourth to seventh day of sgndrome, persisting beyond physiologic jaundice, and with no other identifiable cause, probably resulting from a lucry component that inhibits uridine diphosphoglucuronic acid UDPGA glucuronyl transferase, thus resulting in a prolonged unconjugated hyperbilirubinemia.

These two types, along with Gilbert’s syndrome, Dubin—Johnson syndrome, and Rotor syndrome, make up the five known hereditary defects in bilirubin metabolism.

Lucey Driscoll syndrome — CheckOrphan

Obtain coagulation profile and bleeding time. Usually all siblings are affected. Unlike Gilbert’s syndrome, only a few causes of CNS are known. Genetic counseling can help families understand the condition, its risks of recurring, and how to care for the person.

Lucey Driscoll syndrome

Pediatrics Revolvy Brain revolvybrain. The disorder results in a form of nonhemolytic jaundice, which results in high levels of unconjugated bilirubin and often leads to brain damage in infants. Cases transmitted as an autosomal recessive trait gene map locus is 2q37 have been reported. Breast mild sic jaundice: Rapid Recognition and Perioperative Implications.

Symptoms – Lucet Driscoll syndrome Hyperbilirubinemia. Prognosis – Lucey Driscoll syndrome Not supplied. Excessive jaundice result in kernicterus llucey cause complications such as brain damage.

Serum bilirubin levels normalized by the time the infants were 4 lufey old. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.


The high levels are poisonous to the brain and can cause death. Diagnosis Type I This is a very r The documents contained in this web site are presented for information purposes only.

Lucey–Driscoll syndrome

However, maximal body weight loss during the neonatal period was the only independent risk factor for the development of neonatal hyperbilirubinemia odds ratio of 1. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Contributions to CheckOrphan in the United States and Switzerland are tax-exempt to the extent provided by law.

Phototherapy with blue light is used to treat the high level of bilirubin. An exchange transfusion is sometimes necessary if the levels are extremely high. List of diseases L topic This is a list of diseases starting with the letter “L”.

Breast Milk Jaundice Transient nonhemolytic unconjugated hyperbilirubinemia is observed in breast-fed but not bottle-fed babies of mothers whose breast milk contains pregnane-3 alpha ,20 beta -diol that competitively inhibits hepatic glucuronyltransferase activity in vitro. CheckOrphan is a c 3 nonprofit organization.

Prevention – Lucey Driscoll syndrome Not supplied. This article relies entirely on a single source Relevant discussion may be found on the talk page.

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