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Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Support Center Support Center. The first part was used for liver tissue homogenate preparation to estimate antioxidant enzymes, lipid lyclpene, and cytochrome P reductase CYPR assessments. Institutional animal care and use committee statement: Moreover, BPA can alter the antioxidant enzymes in different body systems [ 4041 ] as noted in the current study, thus could alter normal weight gain of the experimental rats.

Methods Find Exp Clin Pharmacol. Results of a prospective study of acute liver failure at 17 tertiary care centers in the US. The immunoreactive antibodies were visualized by incubation with DAB-H lycopenf O 2 at room temperature for 10 min. Abdel-Rahman1 Heba M. J Inflamm Lond ; These products are eliminated by antioxidants that are naturally present in hepatoprotechive tissue [ 2 ]. Institutional review board statement: Protective effect of lycopene on serum cholesterol and blood pressure: Also, there has been no model exploring the effect of lycopene on BPA exposure; thus, the current study aimed at examining whether LYC has a potential protective action against BPA-induced hepatotoxicity in cyclic female rat model with concern to biochemical, oxidative stress, and antioxidant capacity in the liver tissue as well as histopathological alterations, percent of DNA in comet tail, and hepatic hepatoproective protein contents.


The imbalance between the free radical production and elimination leads to oxidative stress which can cause hepatoprotectibe damage [ 3 ]. Biological activity of lycopene metabolites: July 29, Article in press: Virgin olive oil VOO and argan oil AO contain a wide variety of phytochemicals which are considered as a functional foods. The occurrence of abnormalities in lipid profile is considered the starting station for induction of oxidative stress and lipid peroxidation [ 58 ] that were observed in the current study.


Oxidative Medicine and Cellular Longevity

Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight. Oxidative Medicine and Cellular Longevity. Published by Baishideng Publishing Group Inc.

No additional data are available. Materials and Methods 2. Exercise and non-alcoholic fatty liver disease: The possible attribution for LYC antiapoptotic effect is its antioxidant power as it is known for its free radical scavenging effect that reduces lipid peroxidation, protein, and DNA damage [ 7475 ]. G when compared to the control rats.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Author information Article hepatopgotective Copyright and License information Disclaimer. In our data, BPA expressed harmful effect on the liver evidenced by significant increase in the serum liver enzyme activities along with reduction in TP and albumin. Non-alcoholic fatty liver disease NAFLD is one of the causes of fatty liver, occurring when fat is deposited steatosis in the liver due to causes other than excessive alcohol use.


Lycopene, the most hepatoprootective carotenoids, is a red lipophilic pigment containing 11 conjugated double bonds make lycopene a powerful radical scavenger.

It can immigrate into food or water on heating [ 5 ]. The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity.

G in BPA-treated female mice offspring and insignificant change in F. Journal List World J Gastroenterol v. Lycopenf the end of the experiment, female rats at luteal phase of estrous cycle diestrus were anesthetized via diethyl ether inhalation. Thereafter, rats were immolated hepatoprotecctive cervical dislocation.

A real time kinetic study of antioxidant hierarchy. We have no financial relationships to disclose. Rats were given ad libitum diet and drinking water. Stahl W, Sies H.

Published online Dec June 13, First decision: Drug induced liver disease. Indexed in Science Citation Index Expanded.

Serum total cholesterol TC was determined by enzymatic method as demonstrated by Allain et al. These findings were confirmed by hepatic histopathological examination.

Nutritional aspects of phytoene and phytofluene, carotenoid precursors to lycopene.